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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant Human MERTK/MER/Receptor tyrosine kina250克￥ 11
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Recombinant Human MERTK/MER/Receptor tyrosine kinaGV-P02052-10ug￥ 1800.001
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Recombinant Human MERTK/MER/Receptor tyrosine kinaGV-P02052-50ug￥ 4720.001
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Recombinant Human MERTK/MER/Receptor tyrosine kinaGV-P02052-500ug￥ 13520.001
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Recombinant Human MERTK/MER/Receptor tyrosine kinaGV-P02052-1mg￥ 20400.001
产品简介
| Known as | Tyrosine-protein kinase Mer/Proto-oncogene c-Mer/Receptor tyrosine kinase MerTK/MERTK/MER |
| Derived from | Human Cells |
| Purity | Greater than 90% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.Immobilized Human CADM1-Fc (Cat#C759) at 2μg/ml (100 μl/well) can bind Human CRTAMV-His(Cat#C331).The ED50 of Human CRTAMV-His(Cat#C331)is 4.905 ug/ml . |
| Background | Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganization. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE)， deficiency in MERTK are the cause of retinitis pigmentosa. |
| 规格 | 10ug50ug500ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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