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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant Mouse IL-21/Interleukin-2148T/96T￥ 0.001
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Recombinant Mouse IL-21/Interleukin-21GV-P02108-10ug￥ 1800.001
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Recombinant Mouse IL-21/Interleukin-21GV-P02108-50ug￥ 4720.001
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Recombinant Mouse IL-21/Interleukin-21GV-P02108-500ug￥ 14640.001
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Recombinant Mouse IL-21/Interleukin-21GV-P02108-1mg￥ 20400.001
产品简介
| Known as | Interleukin-21;IL-21;IL21;Il21 |
| Derived from | E.coli |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.Loaded Human TIGIT-Fc(Cat#CS92) on Protein A Biosensor, can bind Human PVR-His(Cat#C622) with an affinity constant of 4.22 nM as determined in BLI assay.Loaded Cynomolgus TIGIT-Fc(Cat#CW11) on Protein A Biosensor, can bind Human PVR-His(Cat#C622) with an affinity constant of 8.77 nM as determined in BLI assay. |
| Background | Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells.It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. It is required for the migration of dendritic cells to draining lymph nodes .It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. |
| 规格 | 10ug50ug500ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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