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产品简介
| 基因名 | WAC |
| 英文全称 | WW domain containing adaptor with coiled-coil |
| 别称 | BM-016;FLJ31290;MGC10753;PRO1741;Wwp4 |
| 中文名称 | WW结构域包含带螺旋线圈的适配蛋白 |
| Uniprot | Q9BTA9 |
| GeneID | 51322 |
| 交叉反应(推测) | Human Mouse |
| 氨基酸大小 | 23kDa |
| 表达氨基酸 | 1-210aa |
| Background | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) ref.Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription ref.Regulates the cell-cycle checkpoint activation in response to DNA damage ref.Positive regulator of amino acid starvation-induced autophagy ref.Also acts as a negative regulator of basal autophagy ref.Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex.This leads to the dimerization of the mTORC1 complex and its subsequent activation ref.May negatively regulate the ubiquitin proteasome pathway ref. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Endotoxin | / |
| Bioactive | Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.) |
| 规格 | 10ug50ug100ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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