Recombinant human CALR protein-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

热门关键词：白介素 gibco ELISA试剂盒胎牛血清移液器 ※本公司产品仅供科研实验研究使用，不用于临床诊断 !

产品简介

基因名	CALR
英文全称	calreticulin
别称	cC1qR;CRT;FLJ26680;RO;SSA
中文名称	钙网蛋白
Uniprot	P27797
GeneID	811
交叉反应(推测)	Human Mouse Rat (Bovine Pig Rabbit)
氨基酸大小	43kDa
表达氨基酸	1-393aa
Background	Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum.It is also found in the nucleus, suggesting that it may have a role in transcription regulation.Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors.Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation.Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen.Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven.Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.[provided by RefSeq, Jul 2008]
Application	Immunology research
Derived from	E.coli
Purification	NI-NTA affinity purification
Formulation	Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping	The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage	Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years.
Reconstitution	Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity	Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin	/
Bioactive	Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.)
规格	10ug50ug100ug1mg