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产品简介

基因名	CHMP2A
英文全称	chromatin modifying protein 2A
别称	BC 2; BC2; Charged multivesicular body protein 2a; CHM2A_HUMAN; CHMP2; CHMP2a; Chromatin modifying protein 2a; Chromatin-modifying protein 2a; hVps2 1; hVps2-1; putative breast adenocarcinoma marker; Putative breast adenocarcinoma marker BC-2; Putative breast adenocarcinoma marker BC2; Vacuolar protein sorting associated protein 2 1; Vacuolar protein sorting-associated protein 2-1; Vps2 1; VPS2; Vps2-1; VPS2A;
中文名称	染色质修饰蛋白2A
Uniprot	O43633
GeneID	27243
交叉反应(推测)	Human Mouse (Chicken)
氨基酸大小	24kDa
表达氨基酸	1-222aa
Background	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966).Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712).ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Application	Immunology research
Derived from	E.coli
Purification	NI-NTA affinity purification
Formulation	Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping	The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage	Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years.
Reconstitution	Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity	Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin	/
Bioactive	Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.)
规格	10ug50ug100ug1mg