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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant human FHIT protein48T/96T￥ 36001
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Recombinant human FHIT proteinGV-P04144-10ug￥ 560.001
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Recombinant human FHIT proteinGV-P04144-50ug￥ 1120.001
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Recombinant human FHIT proteinGV-P04144-100ug￥ 1800.001
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Recombinant human FHIT proteinGV-P04144-1mg￥ 11200.001
产品简介
| 基因名 | FHIT |
| 英文全称 | fragile histidine triad gene |
| 别称 | AP3Aase |
| 中文名称 | 脆性组氨酸三联体蛋白 |
| Uniprot | P49789 |
| GeneID | 2272 |
| 交叉反应(推测) | Human Mouse Rat (Bovine A.thaliana) |
| 氨基酸大小 | 16kDa |
| 表达氨基酸 | 1-148aa |
| Background | Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP.Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP.Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways.Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis.Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+transporters, enhancing mitochondrial calcium uptake.Functions as tumor suppressor. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Endotoxin | / |
| Bioactive | Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.) |
| 规格 | 10ug50ug100ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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