Recombinant human TYR protein-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

热门关键词：白介素 gibco ELISA试剂盒胎牛血清移液器 ※本公司产品仅供科研实验研究使用，不用于临床诊断 !

产品简介

基因名	TYR
英文全称	tyrosinase (oculocutaneous albinism IA)
别称	Tyr-DNA phosphodiesterase 2;hTDP2;5'-Tyr-DNA phosphodiesterase;EAPII;EAP2;TTRAP;AD-022
中文名称	酪氨酸酶(眼皮肤白化病)
Uniprot	P14679
GeneID	7299
交叉反应(推测)	Human Mouse (Chicken Bovine)
氨基酸大小	41kDa
表达氨基酸	1-377aa
Background	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate.Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue.The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation.Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2.Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals.Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate.Acts as a regulator of ribosome biogenesis following stress.Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1.Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells.Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation.Involved in non-canonical TGF-beta induced signaling routes.May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.(Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
Application	Immunology research
Derived from	E.coli
Purification	NI-NTA affinity purification
Formulation	Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping	The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage	Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years.
Reconstitution	Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity	Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin	/
Bioactive	Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.)
规格	10ug50ug100ug1mg