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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant human APEX2 protein48T/96T￥ 36001
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Recombinant human APEX2 proteinGV-P04178-10ug￥ 560.001
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Recombinant human APEX2 proteinGV-P04178-50ug￥ 1120.001
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Recombinant human APEX2 proteinGV-P04178-100ug￥ 1800.001
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Recombinant human APEX2 proteinGV-P04178-1mg￥ 11200.001
产品简介
| 基因名 | APEX2 |
| 英文全称 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 |
| 别称 | AP endonuclease XTH2；APEX nuclease 2；APEX nuclease-like 2；AP endonuclease 2 |
| 中文名称 | APEX核酸酶2 |
| Uniprot | Q9UBZ4 |
| GeneID | 27301 |
| 交叉反应(推测) | Human Mouse (Bovine) |
| 氨基酸大小 | 39kDa |
| 表达氨基酸 | 172-521aa |
| Background | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities.Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially.Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents.In the nucleus functions in the PCNA-dependent BER pathway.Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes.Required for proper cell cycle progression during proliferation of peripheral lymphocytes. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Endotoxin | / |
| Bioactive | Unknown. (Ban't be used in biological activity experiments such as cell culture, treatment and diagnosis.) |
| 规格 | 10ug50ug100ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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