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产品简介
| 中文名称 | 小鼠表皮生长因子受体3 |
| 储存条件 | 2-8℃ |
| 有效期 | 6个月 |
| 英文名称 | Mouse HER3/ERBB3 ELISA KIT |
| 英文别名 | C76256 ; Erbb-3 ; Erbb-3r ; Erbb3 ; Erbb3r ; Her3 |
| 反应性 | Mouse |
| 样品类型 | 血清/血浆/细胞培养上清 |
| 检测范围 | 93.75-6000pg/mL |
| 灵敏度 | 46pg/mL |
| 反应时间 | 3h15min |
| 应用 | ELISA |
| 背景 | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
| 规格 | 48T96T |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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