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| 中文名称 | 大鼠β-2微球蛋白检测试剂盒 |
| 储存条件 | 2-8℃ |
| 有效期 | 6个月 |
| 英文名称 | Rat Beta-2 microglobulin / B2M ELISA KIT |
| 英文别名 | B2M |
| 反应性 | Rat |
| 样品类型 | 血清/血浆/细胞培养上清 |
| 检测范围 | 3.125-200pg/ml |
| 灵敏度 | 1.5pg/ml |
| 反应时间 | 3h15min |
| 应用 | ELISA |
| 背景 | B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M (β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M (β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens. B2M (β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to the α3 chain. Unlike α3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M (β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M (β2 microglobulin) can indicate non-progression of HIV. |
| 规格 | 48T96T |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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