暂无数据
产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品简介
| 中文名称 | 人铁调素Elisa试剂盒 |
| 储存条件 | 2-8℃ |
| 有效期 | 6个月 |
| 英文名称 | Human Hepcidin Elisa Kit |
| 英文别名 | HAMP; HEPC; hepcidin antimicrobial peptide; Hepcidin; HEPCPutative liver tumor regressor; HFE2B; HFE2Bhepcidin; LEAP1; LEAP-1; LEAP1PLTR; Liver-expressed antimicrobial peptide 1; PLTR |
| 反应性 | Human |
| 样品类型 | 血清/血浆/细胞培养上清 |
| 检测范围 | 3.1 - 200 pg/mL |
| 灵敏度 | 1.5 pg/mL |
| 背景 | Hepcidin, also known as Liver Expressed Antimicrobial Protein 1 (LEAP-1), is a peptide hormone that is involved in the regulation of iron metabolism. It is synthesized as a preprohormone that is cleaved intracellularly and secreted as a mature 25 amino acid peptide . Hepcidin contains eight cysteine residues that form four disulfide bonds which appear to be important for stability in biological fluids. It is predominantly expressed, processed, and secreted by hepatocytes. Hepcidin expression is positively regulated by inflammation via IL-6/JAK2/ STAT3 signaling, endoplasmic reticulum stress, and BMP-6. BMP-6-dependent Hepcidin induction involves RGM-C/Hemojuvelin, which acts as a co-receptor for BMP-6. Conversely, Hepcidin expression is negatively regulated by MMP?15/MT2?MMP and multiple erythropoietic stimuli, including anemia, hypoxia, and Erythropoietin. MMP-15 downregulates Hepcidin expression by interacting with and cleaving RGM-C. Hepcidin was originally identified in human blood and urine as an antimicrobial peptide. It has since been shown to regulate iron metabolism. Hepcidin binds the cellular iron exporter Ferroportin, and this interaction results in Ubiquitin-mediated degradation of both Hepcidin and Ferroportin. Degradation of Ferroportin results in reduced iron release from macrophages, hepatocytes, and duodenal enterocytes, suggesting that Hepcidin may be an effector of inflammatory hypoferremia. |
| 规格 | 48T96T |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
(pdf)我要询价
*联系方式：
(可以是QQ、MSN、电子邮箱、电话等，您的联系方式不会被公开)
*内容：
