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| 中文名称 | 小鼠激活素A检测试剂盒 |
| 储存条件 | 2-8℃ |
| 有效期 | 6个月 |
| 英文名称 | Mouse ACV-A/Activin A ELISA KIT |
| 英文别名 | ACV-A，Activin A |
| 中文别名 | 小鼠激活素A检测试剂盒 |
| 样品类型 | 血清/血浆/细胞培养上清 |
| 检测范围 | 62.5-4,000 pg/ml |
| 灵敏度 | 31.25pg/ml |
| 反应时间 | 3h15min |
| 应用 | ELISA |
| 背景 | Activin A is two activin βA subunits and belongs to the TGF-β protein superfamily.[1]. Activin A is produced in the gonads, pituitary gland, placenta, and other organs. Activin A is more plentiful in the adipose tissue of obese, compared to lean persons.[2] Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation. Its action in wound repair and skin morphogenesis is through stimulation of keratinocytes and stromal cells in a dose-dependent manner.[3] Lack of activin during development results in neural developmental defects. Upregulation of Activin A drives pluripotent stem cells into a mesoendo dermal fate, and thus provides a useful tool for stem cell differentiation and organoid formation.[4] Activin A is overexpressed in many cancers. It was shown to promote tumorigenesis by hampering the adaptive anti-tumor immune response in melanoma.[27] Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts. Activin A promotes the proliferation of adipocyte progenitor cells, while inhibiting their differentiation into adipocytes.[2] Activin A also increases inflammatory cytokines in macrophages.[2] In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. |
| 规格 | 48T96T |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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