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产品简介
实际分子量 | 28kDa |
英文名称 | Anti-RSPO2 Polyclonal Antibody |
靶标 | RSPO2 |
别名 | R-spondin-2;Roof plate-specific spondin-2;hRspo2;UNQ9384/PRO34209;CRISTIN2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin family, member 2; |
宿主 | Rabbit |
预测交叉反应 | Bovine;Zebrafish |
稀释比例 | WB 1:1000-3000. |
Gene ID | 340419 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | Q6UXX9 |
蛋白分子量 | 20/21/28kDa |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Cytoplasm |
免疫原 | Recombinant protein of human RSPO2 |
亚型 | IgG |
纯化方法 | Affinity purification |
背景资料 | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). |
Public Immunogen Range | 1-177aa |
克隆类型 | Polyclonal Antibody |
交叉反应 | Human;Mouse;Rat |
应用 | WB |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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