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产品简介
英文名称 | Anti-SIRPA Polyclonal Antibody |
别名 | SHP substrate 1;SHPS-1;Bit;Sirp-alpha-1;Sirp-alpha-2;Sirp-alpha-3;CD172a;BIT;MFR;MYD1;PTPNS1;SHPS1;SIRP |
宿主 | Rabbit |
稀释比例 | IHC 1:25-100. |
Gene ID | 140885 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | P78324 |
蛋白分子量 | 55kDa |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Cytoplasm |
免疫原 | A synthetic peptide of human SIRPA |
亚型 | IgG |
纯化方法 | Affinity purification |
背景资料 | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
Public Immunogen Range | 25-75/504aa |
克隆类型 | Polyclonal Antibody |
交叉反应 | Human |
应用 | IHC |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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