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产品简介
| 英文名称 | Anti-CHMP2A Polyclonal Antibody |
| 别名 | BC 2;BC2;Charged multivesicular body protein 2a;CHM2A_HUMAN;CHMP2;CHMP2a;Chromatin modifying protein 2a;Chromatin-modifying protein 2a;hVps2 1;hVps2-1;putative breast adenocarcinoma marker;Putative breast adenocarcinoma marker BC-2;Putative breast adenocarcinoma marker BC2;Vacuolar protein sorting associated protein 2 1;Vacuolar protein sorting-associated protein 2-1;Vps2 1;VPS2;Vps2-1;VPS2A; |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 27243 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O43633 |
| 蛋白分子量 | 25kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human CHMP2A |
| 亚型 | IgG |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 背景资料 | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Public Immunogen Range | 1-222aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanMouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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