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产品简介
| 英文名称 | Anti-FBXW4 Polyclonal Antibody |
| 别名 | FBXW4;DAC;FBW4;FBWD4;SHFM3;SHSF3 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:8000-12000. IHC 1:50-200. |
| Gene ID | 6468 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P57775 |
| 蛋白分子量 | 46kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human FBXW4 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. |
| Public Immunogen Range | 1-293aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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