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产品简介
| 英文名称 | Anti-FZD6 Polyclonal Antibody |
| 靶标 | FZD6 |
| 别名 | hFz6;Fz-6;Frizzled-6 |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 8323 |
| 保存 | Store at -73°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O60353 |
| 蛋白分子量 | 76/79kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.56. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human FZD6 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). |
| Public Immunogen Range | 640-690/706aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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