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产品简介
| 英文名称 | Anti-RFX3 Polyclonal Antibody |
| 靶标 | RFX3 |
| 别名 | Regulatory factor X 3;Transcription factor RFX3; |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:2000-5000. IHC 1:50-200. |
| Gene ID | 5991 |
| 保存 | Store at -81°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P48380 |
| 蛋白分子量 | 46/79/84kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.64. |
| 亚细胞定位 | Nucleus |
| 免疫原 | A synthetic peptide of human RFX3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). |
| Public Immunogen Range | 245-295/749 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPredicted:Xenopus tropicalis MonkeyMouse |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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