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产品简介
| 英文名称 | Anti-GNAI3 Polyclonal Antibody |
| 靶标 | GNAI3 |
| 别名 | G(i) alpha-3;87U6;ARCND1; |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 2773 |
| 保存 | Store at -56°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P08754 |
| 蛋白分子量 | 41kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.39. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human GNAI3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K+ channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). |
| Public Immunogen Range | 304-354/354 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPredicted:Hamster Guinea pigRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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