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产品简介
| 英文名称 | Anti-DCLRE1C Polyclonal Antibody |
| 靶标 | DCLRE1C |
| 别名 | DCLRE1C;A-SCID;DCLREC1C;RS-SCID;SCIDA;SNM1C |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 64421 |
| 保存 | Store at -66°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q96SD1 |
| 蛋白分子量 | 50/65/78kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.49. |
| 亚细胞定位 | Nucleus |
| 免疫原 | A synthetic peptide of human DCLRE1C |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. |
| Public Immunogen Range | 225-275/692 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPredicted:ChimpanzeeRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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