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产品简介
| 英文名称 | Anti-PD-1/CD279 Polyclonal Antibody |
| 靶标 | PD-1/CD279 |
| 别名 | CD279, hPD 1, hPD l, PD 1, PD1, PD-1, PDCD1, programmed cell death 1, Protein PD 1, SLEB2 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:300-1000. IHC 1:400-1600.IF 1:50-500. |
| Gene ID | 5133 |
| 保存 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
| Swiss Prot | Q15116 |
| 蛋白分子量 | 32kDa |
| 储存液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 亚细胞定位 | Cell membrane |
| 免疫原 | Fusion protein of human PD-1/CD279 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE , which is larger than its predicted mass of 32 kDa (PMID: 8671665; 17640856; 17003438). |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanMouse |
| 应用 | WBELISAIFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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