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产品简介
| 英文名称 | Anti-PD-L1/CD274 Polyclonal Antibody |
| 靶标 | PD-L1/CD274 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-1000. IHC 1:300-1200.IF 1:10-100.IP 0.5-4.0 ug for IP and 1:500-2000 for WB |
| Gene ID | 29126 |
| 保存 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
| Swiss Prot | Q9NZQ7 |
| 蛋白分子量 | 33kDa |
| 储存液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 亚细胞定位 | Cell membrane |
| 免疫原 | Fusion protein of human PD-L1/CD274 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage (PMID: 25609200; 17076679). The apparent molecular weight has also been reported as 45-70 kDa, major glycosylated form of 45-50 kDa and multiple post-translational modifications form of 65-70 kDa (PMID: 18760278; 16493058). |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBELISAIPIFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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