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产品简介
| 靶标 | IL33 |
| 别名 | C9orf26;DVS27;IL1F11;NF-HEV;NFEHEV |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 90865 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O95760 |
| 蛋白分子量 | 26/31kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus Cytoplasm |
| 免疫原 | Recombinant protein of human IL33 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. |
| Public Immunogen Range | 1-270aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | IHC |
| 规格 | 50ul100ul |
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