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产品简介
| 靶标 | ABL1 |
| 别名 | Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine protein kinase 1;Abl 1;ABL;ABL proto oncogene 1 non receptor tyrosine kinase;ABL1;ABL1_HUMAN;bcr/abl;bcr/c abl oncogene protein;c ABL;c abl oncogene 1 non receptor tyrosine kinase;c abl oncogene 1 receptor tyrosine kinase;c ABL1;JTK7;p150;Proto oncogene tyrosine protein kinase ABL1;Proto-oncogene c-Abl |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 25 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P00519 |
| 蛋白分子量 | 123/125kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | A synthetic peptide of human ABL1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. |
| Public Immunogen Range | 195-245/1130aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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