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产品简介
| 靶标 | MDR1 |
| 别名 | P-Glycoprotein;Multi Drug Resistance Associated Protein;ABCB1;ATP-binding cassette sub-family B (MDR/TAP);member 1;ABC20;CD243;CD243 antigen;CLCS;Multidrug resistance protein 1;P glycoprotein 1;p-GP;gp170; |
| 宿主 | Rabbit |
| 稀释比例 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 |
| Gene ID | 5243 |
| 保存 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Swiss Prot | P21447 |
| 蛋白分子量 | 141kDa |
| 储存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Cell membrane;Multi-pass membrane protein. |
| 免疫原 | KLH conjugated synthetic peptide derived from human MDR1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas. |
| Public Immunogen Range | 21-100/1272aa |
| 克隆类型 | Polyclonal Antibody |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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