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产品简介
| 英文名称 | Anti-DCTN1(N-term) Monoclonal Antibody |
| 别名 | DAP-150;DP-150;P135;Dynactin 1 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:500. |
| Gene ID | 1639 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q14203 |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 蛋白分子量 | 127/137/139/141/142kDa |
| 亚细胞定位 | Cytoplasm cytoskeleton |
| 免疫原 | Purified recombinant DCTN1 protein fragments expressed in E.coli |
| 亚型 | IgG2b |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 3D5-C6-D5 |
| 背景资料 | This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).[provided by RefSeq, Oct 2008] |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | Human |
| 应用 | WBIP |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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