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产品简介
| 英文名称 | Anti-hnRNP U Monoclonal Antibody |
| 别名 | EIEE54;hnRNPU;HNRNPU-AS1;HNRPU;pp120;SAF-A;SAFA;U21.1;hnRNPU;HNRNPU-AS1;HNRPU;SAF-A;SAFA;U21.1 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. |
| Gene ID | 3192 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q00839 |
| 蛋白分子量 | 110kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell surface Cytoplasm Nucleus |
| 免疫原 | Purified recombinant human hnRNP U protein fragments expressed in E.coli. |
| 亚型 | IgG1 |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 1B11-H2-B7 |
| 背景资料 | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Public Immunogen Range | Purified recombinant human hnRNP U protein fragments expressed in E.coli. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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