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产品简介
| 英文名称 | Anti-FEN1 Monoclonal Antibody |
| 别名 | FEN-1;MF1;RAD2;DNase IV;Flap endonuclease 1;flap structure endonuclease 1;hFEN 1;Maturation factor 1 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. ICC 1:400. |
| Gene ID | 2237 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P39748 |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 蛋白分子量 | 36/43kDa |
| 亚细胞定位 | Mitochondrion Nucleus nucleolus nucleoplasm |
| 免疫原 | Purified recombinant human FEN1 protein fragments expressed in E.coli. |
| 亚型 | IgG1 |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 7H8-F4-C11 |
| 背景资料 | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions.[provided by RefSeq,Jul 2008] |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanHamsterMonkeyRatMouse |
| 应用 | WBICC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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