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产品简介
| 英文名称 | Anti-HSPA5(C-term) Monoclonal Antibody |
| 别名 | BIP;GRP78;HEL-S-89n;MIF2 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. IHC 1:50. |
| Gene ID | 3309 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P11021 |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 蛋白分子量 | 72kDa |
| 亚细胞定位 | Cytoplasm Endoplasmic reticulum lumen Melanosome |
| 免疫原 | Purified recombinant human HSPA5 (C-terminus) protein fragments expressed in E.coli. |
| 亚型 | IgG1 |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 9E4-2A7-H6 |
| 背景资料 | The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanRat |
| 应用 | WBIHCICC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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