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产品简介

英文名称	Anti-CDK5(N-term) Monoclonal Antibody
别名	LIS7;PSSALRE
宿主	Mouse
稀释比例	WB 1:500. IHC 1:150.
Gene ID	1020
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q00535
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
蛋白分子量	33kDa
亚细胞定位	Cell junction Cell membrane Cell projection Cytoplasm Nucleus Perikaryon Peripheral membrane protein growth cone lamellipodium postsynaptic cell membrane postsynaptic density synapse
免疫原	Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
亚型	IgG1
性状	液体
纯化方法	Affinity purification
克隆号	2E8-F9-B7-C11
背景资料	Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.
Public Immunogen Range	Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
克隆类型	Monoclonal Antibody
交叉反应	HumanMonkeyRatMouse
应用	WBICC
规格	50ul100ul