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产品简介
| 英文名称 | Anti-TAB1(N-term) Monoclonal Antibody |
| 别名 | TAB 1;TAK1;TGF beta activated kinase 1 binding protein 1;MAP3K7IP 1 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. |
| Gene ID | 10454 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q15750 |
| 蛋白分子量 | 55kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli. |
| 亚型 | unknown |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 3D10-G10-B6 |
| 背景资料 | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported |
| Public Immunogen Range | Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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