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产品简介
| 英文名称 | Anti-NUP98 Monoclonal Antibody |
| 别名 | ADIR2;NUP196;NUP96 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. |
| Gene ID | 4928 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P52948 |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 蛋白分子量 | 198/187/98kDa |
| 亚细胞定位 | Nucleoplasmic side Nucleus Nucleus membrane Peripheral membrane protein nuclear pore complex |
| 免疫原 | Purified recombinant human NUP98 protein fragments expressed in E.coli. |
| 亚型 | IgG1 |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 3B8-D7-H10 |
| 背景资料 | Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
| Public Immunogen Range | Purified recombinant human NUP98 protein fragments expressed in E.coli. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | Human |
| 应用 | WBIP |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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