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产品简介
| 英文名称 | Anti-DDB1 Monoclonal Antibody |
| 别名 | DDBA;UV-DDB1;XAP1;XPCE;XPE;XPE-BF |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. |
| Gene ID | 1642 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q16531 |
| 蛋白分子量 | 127kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Purified recombinant human DDB1 protein fragments expressed in E.coli. |
| 亚型 | IgG2b |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 克隆号 | 2D6-B5-E6 |
| 背景资料 | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit.This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage.Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas.However,it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.In addition,Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.[provided by RefSeq,May 2012] |
| Public Immunogen Range | Purified recombinant human DDB1 protein fragments expressed in E.coli. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanMonkeyRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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