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产品简介
英文名称 | Anti-MMP2 Monoclonal Antibody |
别名 | CLG4;CLG4A;MMP-2;MMP-II;MONA;TBE-1 |
宿主 | Mouse |
稀释比例 | WB 1:1000. |
Gene ID | 4313 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | P08253 |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
蛋白分子量 | 74kDa |
亚细胞定位 | Cytoplasm Membrane Mitochondrion Nucleus Secreted extracellular matrix extracellular space |
免疫原 | Purified recombinant human MMP2 protein expressed in E.coli. |
亚型 | IgG1 |
性状 | 液体 |
纯化方法 | Affinity purification |
克隆号 | 3A8-C1-E8 |
背景资料 | This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
克隆类型 | Monoclonal Antibody |
交叉反应 | Transfected RatTransfected Human |
应用 | WBIF |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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