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产品简介
| 英文名称 | Anti-MECP2 Polyclonal Antibody |
| 别名 | AUTSX3;MRX16;MRX79;MRXS13;MRXSL;PPMX;RS;RTS;RTT |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. |
| Gene ID | 4204 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P51608 |
| 蛋白分子量 | 52kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus |
| 免疫原 | A synthetic peptide of human MECP2 |
| 亚型 | IgG |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 背景资料 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Public Immunogen Range | A synthetic peptide of human MECP2 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | MouseRat |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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