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产品简介
| 英文名称 | Anti-MAP3K7 Monoclonal Antibody |
| 别名 | CSCF;FMD2;TAK1;MEKK7;TGF1a |
| 宿主 | Mouse |
| 稀释比例 | WB 1:1000. |
| Gene ID | 6885 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O43318 |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 蛋白分子量 | 54/57/64/67kDa |
| 亚细胞定位 | Cell membrane Cytoplasm Cytoplasmic side Peripheral membrane protein |
| 免疫原 | Recombinant protein of human MAP3K7 |
| 亚型 | IgG2b |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 背景资料 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6 various cytokines including interleukin-1 (IL-1) transforming growth factor-beta (TGFB) TGFB-related factors like BMP2 and BMP4 toll-like receptors (TLR) tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1 MAP2K3/MKK3 MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling plays a major role in the activation of MAPK8/JNK1 but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanMonkeyRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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