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| 英文名称 | Anti-CALR Polyclonal Antibody |
| 别名 | CRT;HEL-S-99n;RO;SSA;cC1qR |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-5000. IHC 1:50-200. |
| Gene ID | 811 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P27797 |
| 蛋白分子量 | 48kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell surface Cytoplasm Endoplasmic reticulum lumen Sarcoplasmic reticulum lumen Secreted cytosol extracellular matrix extracellular space |
| 免疫原 | Recombinant protein of human CALR |
| 亚型 | IgG |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 背景资料 | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. |
| Public Immunogen Range | Recombinant protein of human CALR |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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