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产品简介
| 英文名称 | Anti-NR3C1 Polyclonal Antibody |
| 别名 | GCCR;GCR;GCRST;GR;GRL;glucocorticoid receptor |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:3000. |
| Gene ID | 2908 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04150 |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 蛋白分子量 | 52/76/61/65/82/86kDa |
| 亚细胞定位 | Cytoplasm Mitochondrion Nucleus Nucleus |
| 免疫原 | A synthetic peptide of human NR3C1 |
| 亚型 | IgG |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 背景资料 | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. |
| Public Immunogen Range | 30-80/777aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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