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产品简介
| 英文名称 | Anti-USP8 Polyclonal Antibody |
| 别名 | HumORF8;SPG59;UBPY;KIAA0055;hUBPy;Ubiquitin thioesterase 8 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:5000-8000. IHC 1:50-200. |
| Gene ID | 9101 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P40818 |
| 蛋白分子量 | 128/115kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm Endosome membrane Nucleus Peripheral membrane protein |
| 免疫原 | A synthetic peptide of human USP8 |
| 亚型 | IgG |
| 性状 | 液体 |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 背景资料 | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. |
| Public Immunogen Range | 220-270/1118aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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