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产品简介
英文名称 | Anti-PARP Monoclonal Antibody |
别名 | ADPRT;ADPRT 1;ADPRT1;ARTD1;PARP;PARP-1;PPOL;pADPRT-1;poly(ADP-ribose) polymerase 1 |
稀释比例 | WB 1:2000-4000. IHC 1:50-200. |
Gene ID | 142 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | P09874 |
蛋白分子量 | 116kDa |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Nucleus nucleolus |
免疫原 | A synthetic peptide coupled to KLH |
亚型 | IgG1 |
性状 | 液体 |
纯化方法 | Affinity purification |
克隆号 | M3 |
背景资料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
Public Immunogen Range | A synthetic peptide coupled to KLH |
克隆类型 | Monoclonal Antibody |
交叉反应 | Human |
应用 | WBIHC |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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