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| 英文名称 | Anti-VWA5A Polyclonal Antibody |
| 别名 | BCSC1;BCSC-1;LOH11CR2A |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. IHC 1:50-150. |
| Gene ID | 4013 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O00534 |
| 蛋白分子量 | 86 kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human VWA5A |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. |
| 克隆类型 | rabbit polyclonal |
| 交叉反应 | Human |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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