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产品简介
| 英文名称 | Anti-AR Polyclonal Antibody |
| 别名 | KD;AIS;AR8;TFM;DHTR;SBMA;HYSP1;NR3C4;SMAX1;HUMARA |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:10-100. |
| Gene ID | 367 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P10275 |
| 蛋白分子量 | 99 kDa/44 kDa/67 kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus Cytoplasm |
| 免疫原 | A synthetic peptide of human AR |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.? |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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