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产品简介
| 英文名称 | Anti-NR3C1 Polyclonal Antibody |
| 别名 | GCCR; GCR; GCRST; GR; GRL; glucocorticoid receptor |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:5000-8000. IHC 1:50-200. |
| Gene ID | 2908 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04150 |
| 蛋白分子量 | 52/76/61/65/82/86kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Mitochondrion Nucleus Nucleus |
| 免疫原 | Recombinant protein of human NR3C1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696).Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). |
| Public Immunogen Range | 1-300aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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