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产品简介
| 英文名称 | Anti-COL4A1 Polyclonal Antibody |
| 别名 | COL4A1;BSVD;RATOR;collagen alpha-1(IV) chain;ICH;HANAC;POREN1;arresten |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-1:2000. |
| Gene ID | 1282 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P02462 |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 蛋白分子量 | 161kDa/50kDa |
| 亚细胞定位 | Cytoplasm Basement membrane ExtraCellular space ExtraCellular matrix |
| 免疫原 | A synthetic peptide of human COL4A1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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