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产品简介
| 英文名称 | Anti-PPIF Polyclonal Antibody |
| 别名 | CyP-D;CypD;CyP-M;Rotamase F |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:2000-1:5000. IHC 1:50-200.IF 1:50-200. |
| Gene ID | 10105 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P30405 |
| 蛋白分子量 | 16/22kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human PPIF |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. |
| Public Immunogen Range | 110-160/207aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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