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产品简介
| 英文名称 | Anti-PINK1 Polyclonal Antibody |
| 别名 | BRPK;PARK6;PINK1;PTEN induced putative kinase 1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-1000. IHC 1:50-500. IF 1:50-500. |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9BXM7 |
| 蛋白分子量 | 63 kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Membrane Mitochondrion Mitochondrion inner membrane Mitochondrion outer membrane |
| 免疫原 | PINK1 fusion protein Ag19825 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane where it is cleaved into a 52 kDa mature form. The half life of the mature form of PINK1 is very short and it was proposed that the proteasome is involved in its degradation. The gene of PINK1 maps to chromosome 1p36.12. Two alternatively spliced variants exist, the shorter isoform (30 kDa) produced by alternative splicing. Mutations in the PINK1 gene cause autosomal recessive early-onset Parkinson's disease. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBELISAIFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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