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产品简介
| 英文名称 | Anti-GCK Monoclonal Antibody |
| 别名 | GCK;GK, GLK;Glucokinase;glucokinase (hexokinase 4);Hexokinase 4;Hexokinase D;Hexokinase type IV;HHF3;HK IV;HK4;HKIV;HXKP;MODY2 |
| 宿主 | Mouse |
| 稀释比例 | WB 1:5000-20000. IHC 1:300-1000. |
| Gene ID | 2645 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P35557 |
| 蛋白分子量 | 52kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Mitochondrion Nucleus |
| 免疫原 | GCK fusion protein |
| 亚型 | IgG1 |
| 纯化方法 | Affinity purification |
| 背景资料 | Glucokinase (GCK) is a structurally and functionally unique member of hexokinase family. It is expressed only in mammalian liver and pancreatic islet beta cells. Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism.The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Moreover, GCK has been found to have relationship with diabetes. Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) and familial hyperinsulinemic hypoglycemia type 3 (HHF3). It has 3 isoforms produced by alternative splicing with the same molecular mass of 52 kDa. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanPigRatMouse |
| 应用 | WBELISAIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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