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产品简介
| 英文名称 | Anti-HMGCR Polyclonal Antibody |
| 别名 | HMGCR;LDLCQ3;HMGCR |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-4000. IHC 1:50-200. IF 1:50-200. |
| Gene ID | 3156 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04035 |
| 蛋白分子量 | 92/97/99kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Endoplasmic reticulum membrane Multi-pass membrane protein |
| 免疫原 | Recombinant protein of human HMGCR |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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