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产品简介
| 英文名称 | Anti-LIG4 Polyclonal Antibody |
| 别名 | LIG4;LIG4S |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| Gene ID | 3981 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P49917 |
| 蛋白分子量 | 104kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus |
| 免疫原 | Recombinant protein of human LIG4 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WBIF |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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