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产品简介
| 英文名称 | Anti-Villin-1 Monoclonal Antibody |
| 别名 | VIL;VIL1;Villin 1;Villin-1;Villin1;D2S1471;OTTHUMP00000164145;VILI_HUMAN |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. IHC-P 1:20-200. IHC-F 1:20-200. ICC 1:100-500 . IF 1:50-200. |
| Gene ID | 7429 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P09327 |
| 蛋白分子量 | 93kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant human villin protein |
| 亚型 | IgG |
| 性状 | liquid |
| 纯化方法 | Affinity purification |
| 背景资料 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. |
| 克隆类型 | Monoclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIFICCIHC-FIHC-P |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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